A deviation as small as 1°C during sterilization or the selection of an inappropriate impeller can have catastrophic consequences in bioprocessing—resulting in contamination, reduced yield, or production downtime that may cost millions per minute.
The design of bioreactors is primarily determined by the method of energy supply and aeration of the medium. Based on these criteria, bioreactors can be categorized into the following types:
From a technological perspective, fermentation processes can be classified into the following microbiological methods: aerobic and anaerobic cultivation; solid-phase, surface, and deep cultivation; as well as batch and continuous cultivation. This article will cover surface and deep cultivation, as well as batch and continuous cultivation. Surface Fermentation on Liquid Substrates. Surface fermentation is conducted in…
Fundamentals of Fermentation Fermentation encompasses a series of sequential operations, beginning with the introduction of seed material into a pre-prepared and thermally regulated medium, followed by the progression of cell growth or biosynthesis of the desired product. Upon completion of the fermentation process, a complex mixture is formed, comprising producer cells, residual nutrients, and biosynthetic…
